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Tim Van Hauwermeiren, CEO of arGEN-X commenting on the progress with the Company’s own antibody pipeline said: Given the outstanding manufacturability of our human antibody leads, we are now in a position to further develop candidates with the best possible drug characteristics in record time.ĪrGEN-X intends to use the power of the SIMPLE Antibody™ platform to build its business by making its technology and know-how available to biopharmaceutical companies through selective strategic partnerships and adding more exciting programs to its preclinical portfolio. In just a matter of weeks, we managed to generate an incredibly diverse panel of ultra-potent antagonist antibodies, effectively blanketing these targets in a way that, according to our expert collaborators, has never been seen before.
#Argen meaning full#
We have tested its full potential by selecting as targets two highly challenging receptors known to play a pivotal role in cancer. The work that we have conducted in the past six months has clearly demonstrated the power of our SIMPLE Antibody™ platform and its potential to transform the development of therapeutic antibodies. Hans de Haard, CSO of arGEN-X commenting on the SIMPLE Antibody™ platorm said:
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SIMPLE Antibodies routinely exhibit gold-standard potency and manufacturability without the need for additional engineering, making them an ideal starting point for a therapeutic antibody development program.These variable domains are combined with human constant domains to generate full size, fully human therapeutic antibodies. ARGX-109 was chosen from a panel of 65 functional antagonists generated against IL-6, a cytokine that plays an important role in several autoimmune, inflammation and oncology indications.ĪrGEN-X’ SIMPLE Antibody™ Platform is based on the active immunisation of outbred Camelids with target antigen to deliver antibodies whose variable regions are virtually identical to those of human antibodies. He will also outline the very rapid progress that arGEN-X has made in building its own pipeline with its lead product ARGX-109, which entered preclinical development less than 12 months from the start of the discovery process.
#Argen meaning series#
Tim Van Hauwermeiren, the CEO of arGEN-X, will highlight a series of important technical breakthroughs during his presentation, demonstrating the power of the Company’s SIMPLE Antibody™ platform to deliver multiple, diverse, ultra-potent functional antibodies that are able to blanket any target, regardless of its complexity.
#Argen meaning update#
Rotterdam, the Netherlands– arGEN-X, a biopharmaceutical company focused on the discovery and development of human monoclonal antibodies using its proprietary SIMPLE Antibody™ platform, announces that it will provide an update on the development of this unique platform and its own antibody pipeline during the BIO-Europe Spring event in Barcelona (March 8-10, 2010).